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The Relationships between Amyloid Precursor Protein Gene Polymorphisms and Alzheimer’s Disease
Li Moxiang, Hao Qian, Liu Ying, An Shu, Guo Xiaoxi, Xu Tianrui*, Yang Yang*
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease which is characterized by cognitive and memory impairment in the brain. As human life expectancy continues to increase， AD has become a huge threat to human health. Its main pathological features are neurofibrillary tangles， loss of neurons， and the presence of senile plaques in the brain， which are mainly caused by the deposition of amyloid peptides. The etiology of AD is complex and varied. However， there are close associations between the polymorphisms of amyloid precursor protein gene on chromosome 21 and AD. Exploring APP polymorphisms will provide valuable clues for better understanding and treatment of AD.
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