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Epigenetic Related Drugs in Cancer Therapy
Wang Zhen, Li Lianyun*, Wu Min*
Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, College of Life Sciences, Wuhan University, Wuhan 430072, China
Abstract: Epigenetic changes refers to heritable changes without DNA sequence alteration. Epigenetic changes play important roles in carcinogenesis， and FDA has approved several epigenetics-related drugs for cancer therapy， mostly inhibitors of DNMT and HDAC. Moreover， a large number of epigenetic drugs are current under clinical studies for cancer therapy， including inhibitors of HATs， HMTs， HDMTs and epigenetic readers， which all have shown strong antitumor activity. This review will summarize the latest advance and future applications of these inhibitors.
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