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The Role of Cdc42 in Breast Cancer
Li Jun1,2#, Zhang Yu3#, Chen Houwen1, Xiong Lixia1*
1Department of Pathophysiology, Basic Medical College, Nanchang University, Nanchang 330006, China; 2Second Clinical Medical College, Nanchang University, Nanchang 330006, China; 3First Clinical Medical College, Nanchang University, Nanchang 330006, China
Abstract: Breast cancer is one of the most common malignant tumors in women. Although the conventional treatment has demonstrated a certain effect， there are still some limitations. Cdc42 (cell division cycle 42) is a kind of small GTP enzyme of Rho family which can be activated via combining with GTP， resulting in effects on various physiological processes such as cytoskeletal changes， polarity establishment， movement and migration. More and more studies show that Cdc42 plays an important role during the genesis and development of breast cancer， suggesting that Cdc42 may serve as a new therapeutic target for breast cancer clinical therapy. This review discussed the role of Cdc42 in the polarity establishment， pseudopod formation of breast cancer cells as well the molecular mechanism of invasion， migration and metastasis. Cdc42-mediated signaling pathway involving breast cancer evolution also be described. Most importantly， we put forward a perspective on Cdc42-targed therapeutic method， providing a new idea for the treatment of breast cancer.
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