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Advances in the Pathogenesis Study of Acute Myeloid Leukemia
Lin Fanlin, Pan Hui, Liu Shengxian, Chen Chen, Wang Li*, Cui Changhao*
School of Life Science and Medicine, DaLian University of Technology Panjin Campus, Panjin 124221, China
Abstract: Acute myeloid leukemia (AML) is one of the most common malignant tumors. Traditional treatment is given priority to with combination chemotherapy， but complete remission or long-term disease-free survival rate is very low. With further investigation on the advanced research， it is stated that the major pathogenesis of AML include fusion gene， signal pathway， leukemia stem cells (LSCs) and bone marrow niche change. The main aim of this review is to summarize recent advanced development on AML mechanism and to further discuss the potential approaches to the treatment of AML.
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