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Current Research and the Regulation Mechanism of FOXL2
Wu Jun, Wang Di, Miao Chunlei, Han Yangyang*
1Plastic Surgery Institute, Weifang Medical University, Weifang 261042, China; 2College of Biological Science and Technology, Weifang Medical University, Weifang 261053, China
Abstract: winged helix/forkhead transcription factor gene 2 (FOXL2)， as a single exon gene， located in 3q22.3 area， which belongs to the large family of forkhead/winged-helix transcription factors， is associated with the blepharophmiosis-ptosis-epicanthus inversus syndrome (BPES)， premature ovarian failure (POF)， and sex determination. Till now， the studies on FOXL2 are still hot issues in related fields. In this review， we summarized the recent research processes of FOXL2， including the genotype-phenotype corresponding relationship between FOXL2 gene mutation and BPES; the roles of FOXL2 in the physiological process of life， and the spatio-temporal expression of FOXL2; besides， we also reviewed the downstream genes and their functions of FOXL2 as a transcription factor. This review aims at helping researchers to understand the function and mechanism of FOXL2 deeply and providing the related theoretical support in this field.
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