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Advances in the Study of Mitophagy
Hu Lei1,2,3, Dai Haiming1,2*
1Department of Pathology and Laboratory Medicine, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China; 2Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China; 3University of Science and Technology of China, Hefei 230026, China
Abstract: Mitophagy plays an important role in mitochondria quality control and development. Mitophagy deficiency causes many diseases， including neurodegenerative diseases， heart diseases and cancer. The key step of mitophagy is the specific recognition of the unwanted mitochondria and phagophore， which is mediated by the interaction between the degradation signal on the unwanted mitochondria and the receptor on the phagophore. Quite a few mitophagy recognition pathways were found recently， however， it is still not clear that these mitophagy signals are started and regulated. This review summarizes the latest advances in the study of mitophagy to provide references for studying mitophagy and related fields.
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