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The Role of p38 Mitogen-Activated Protein Kinase Signaling Pathway in the Sepsis with Multiple Organ Dysfunction Syndrome
Zhang Qi, Shan Feng*
Intensive Care Unit, Affiliated Hospital of Qingdao University, Qingdao 266003, China
Abstract: p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway is an important signal pathway in the conduction process of cell signaling and the occurrence and development of disease. Especially， p38 MAPK plays an crucial role in the disease progression of sepsis and it is one of the key links leading to organ dysfunction. In this paper， the role of p38 MAPK in the release of inflammatory mediators， oxidative stress injury， apoptosis and calcium overload were reviewed， meanwhile， the role of p38 MAPK in organ dysfunction of sepsis and the recent research progress were also discussed.
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