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Progress of Long Non-coding RNA Regulatory Network in Gastric Cancer
Zhu Yinyin, Aihemaitijiang·Kuerban, Shen Zhengjie, Shen Fanhan, Liao Qi*
Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, Ningbo 315211, China
Abstract: Long non-coding RNA (lncRNA) is a kind of functional molecule with length usually more than 200 nt. It can not encode proteins because of lacking a complete reading frame. Gastric cancer (GC) is one of common malignant tumors in our country， whose incidence rate accounts the seconds in all kinds of cancer. More and more accumulated evidences verify that lncRNA participates in the initial and development of GC by regulating gene expression and stability on transcript， post-transcriptional and epigenetic level. It has been already reported that a large number of lncRNA in GC is important in estimating pathological change before cancer， evaluating the curative effect of chemotherapy and prognosis of GC. In this review， we mainly introduce the recent progress of lncRNA regulatory network affects the occurrence and development of GC.
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