Home > Browse Issues > Vol.39 No.10
Effects of SKA2 and Its Regulation Mechanism in Tumorigenesis
Ren Zhouhui1, Yang Tong2, Wang Ping1*
1Key Laboratory of Zhejiang Province for Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, China; 2Oncological Surgery, Ningbo No.2 Hospital, Ningbo 315010, China
Abstract: SKA2 (spindle and kinetochore associated 2) was initially identified in 2006， and it was an important protein of the spindle and kinetochore associated complex. Previous reports showed that it participated in the regulation of cell cycle progression. Recent studies demonstrated that SKA2 was aberrant expressed in a variety of malignant tumors and played a role of oncogene in cancer. In addition， different mechanisms were involved in the regulation of tumor development. Based on our studies， this paper reviewed the role of SKA2 and its regulated mechanism in the tumorigenesis. It provided a novel idea for the further study of oncogene ska2 and targeted therapy of tumor.
CN
EN