Research Progress on AP-1

Abstract: Activator protein-1 (AP-1) is considered as a kind of intracellular transcriptional activator， mainly composed of proto-oncogene encoding protein Jun and Fos， which binds DNA target sequence in the form of homodimer or heterodimer complex， regulating the expression of target genes. AP-1 regulates the expression of target genes in response to the effect of various stimuli on cells， such as cytokines， growth factors， pressure， bacteria and viral infections， and it is also implicated in the regulation of variety of cellular processes， including cell proliferation， differentiation， apoptosis， inflammation and other cellular functions. This review aims to elucidate the structural characteristics， biological function， activity regulation and it’s application in medical study of AP-1.

CSTR: 32200.14.cjcb.2017.10.0013