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SIRT3 Regulates Age-Related Diseases via Mitochondrial Pathway: From Pathogenesis to Therapy
Wang Jianle1, Zhang Xiaolei2, Wang Xiangyang1,2*
1Department of Orthopaedic Surgery, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China; 2Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China
Abstract: One of the common features of age-related diseases is progressive accumulation of defective mitochondria. As a NAD+-dependent protein deacetylase， SIRT3 regulates mitochondrial function and metabolism in response to oxdiative stress. The effects of SIRT3 on mitochondria are complicated， including energy production， antioxidation， mitochondrial dynamics， sustaining membrane potential and mitophagy， etc. SIRT3 has been explored from different aspects. However， there are still few summaries that systematacially illuminate how SIRT3 exerts its functions in protecting organism against age-related diseases. Thus， the aim of this review is to elucidate the relationship between SIRT3 and age-related diseases from pathogenesis to therapy.
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