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Research Progress on the Interactions between Bone Cells and Immune Cells
Du Yongyong1,2, Huyan Ting1,2, Li Jingbao1,2, Dong Dandan1,2, Yang Jiancheng1,2, Shang Peng1,2,3*
1School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China; 2Key Laboratory for Space Biosciences & Biotechnology, Xi’an 710072, China; 3Institute for Research & Development in Shenzhen, Northwestern Polytechnical University, Shenzhen 518057, China
Abstract: As a special connective tissue， bone is the main part of the composition of the skeletal system. Bone formation of osteoblasts and bone resorption of osteoclasts are regulated by endocrine， nervous and immune systems. Skeletal and immune systems are closely related and share many regulatory molecules such as cytokines and transcription factors. The interactions between bone cells and immune cells play a very important role in skeletal system and immune system. An emerging interdisciplinary subject study on the interactions between bone cells and immune cells is called osteoimmunology. Herein， we reviewed the research progress of interplay and interactions and its underlying mechanism between the two kinds of cells and prospected the future development direction of osteoimmunology.
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