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Long Noncoding RNAs Stabilized by Small Nucleolar RNA-Protein (snoRNP) Ends
Xing Yuhang1, Chen Lingling1,2*
1Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; 2School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
Abstract: Eukaryotic DNA transcription and RNA processing produce many long noncoding RNA (lncRNA) species that are longer than 200 nucleotides and lack significant protein-coding potential. Although most lncRNAs transcribed from Pol II promoters have a 7-methyl guanosine (m7G) cap and 3′ polydenosine at their ends as mRNAs， we recently have reported new types of linear lncRNA species that are stabilized by small nucleolar RNA-protein (snoRNP) caps at the 5′ end or of both ends. Here we mainly discuss the biogenesis and functional implication of these unusually processed lncRNAs.
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