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Progress on Antigenic Epitopes of Human Enterovirus 71
Zhu Miao, Zhang Tianfang, Gao Liuying, Dong Changzheng*
Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo 315211, China
Abstract: Human enterovirus 71 (EV71) is the major pathogen of the hand， foot and mouth disease (HFMD). Several inactive EV71 vaccines which elicited remarkable protective efficacy had been developed in China. Two of them had been launched in 2016 and they were expected to benefit many children. Since EV71 escaped the host’s immune response through quick and continual evolution， the vaccines should be updated according to the consecutive surveillance of the genetic variations of the virus， especially for the variations occurring in the antigenic epitopes. We summarized the epitopes from the published papers， introduced the experimental and bioinformatics methods for identifying the epitopes， described the immune response and antiviral mechanisms that the epitopes were involved in， and discussed the potential clinic applications of the epitopes.
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