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The Study in Correlation between Nutrient Stress and Growth Advantage of Drug Resistance Cancer Cells
Cai Yanfei, Ma Xin, Zhang Peng, Chen Yun, Jin Jian*
The Laboratory of Drug Design and Molecular Pharmacology, School of Pharmaceutics, Jiangnan University, Wuxi 214122, China
Abstract: The microenvironment of solid tumor is worse than the normal tissue. But why the tumor cells can still survive and transform into drug resistant tumor cells which causing difficulties on clinical treatment is not clear. This study proposed low nutrition as simulation environment in solid tumor， and investigated the growth status and growth demand of wild type and drug resistant cells， then parsed the specific reason. The wild type and drug resistant breast cancer MCF-7 cells were used to detect cell proliferation， cell migration and the expression level of vascular endothelial growth factor (VEGF). It is found that under the low nutrition condition， the proliferation and migration abilities of drug resistant cells are stronger than that of the wild type cells. What’s more， the VEGF also secrete more in drug resistant cells. These results suggest that the survival ability of drug resistant cells is stronger under nutritional stress， maybe the high expression of VEGF is the main reason.
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