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The Effect of Brand’s Essence of Chicken on Alleviating the Depression
Zhang Wanjing1, Lu Ping1, Ni Yinhua1, Wu Tao1, Wang Xueying2, Fu Zhengwei1*
1College of Biotechnology and Biological Engineering, Zhejiang University of Technology, Hangzhou 310014, China;
2Cerebos Pacific Limited, Singapore 048423, Singapore
Abstract: Depression is a kind of disease with the core symptoms of low mood and lack of interest. Recent clinical studies have shown that circadian rhythm disorder was accompanied in the depression group in most cases， while the mechanism of circadian clock in the regulation of depression has not been systematically studied. In the present study， we used SD rats to establish the depression model via a method of chronic mild unpredictable stimulation (CUMS). Moreover， the chicken active ingredient Brand’s essence of chicken (BEC) was supplemented to analyze its impact on the biological clock system and further explored the potential effect on alleviating the occurrence of depression by ELISA and Real-time PCR. The results showed that BEC could effectively regulate and stabilize the expression phase of clock genes in both suprachiasmatic nucleus (SCN) and peripheral clock including liver and adipose tissue. In addition， BEC treatment alleviated the decrease of exploratory activity and abnormal hormones secretion in serum caused by depression， which further contributed to the prevention and amelioration of depression.
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