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Effects of Early Exposure to Bisphenol A on Neuron and Neuroglia in the Central Nervous System
Xiao Yao, Pan Bingxing, Xu Xiaobin*
Institute of Life Science, Nanchang University, Nanchang 330031, China
Abstract: Bisphenol A (BPA)， a representative environmental estrogen， has been attracting more and more attentions because of its widespread use. Bisphenol A interferes with the normal physiological function of endogenous estrogens by binding to estrogen receptors. A large number of studies have shown that early bisphenol A exposure not only affects the proliferation of neural stem cells， but also bring the irreversible damage for its dendritic development. At the same time， it can affect the development and function of the oligodendrocytes， astrocytes and microglia cells. Therefore， it is necessary to explore the influence of bisphenol A exposure on the nervous system and its specific molecular mechanism.
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