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Regulatory Mechanisms for NPAT
Wang Feiya1, Cong Xiaoxia2, Liu Yufen2, Zhou Yiting2, Zheng Liling2*
1Department of Pathology, Hospital of Pingdingshan Coal Industry Group, Pingdingshan 467000, China; 2Department of Biochemistry and Molecular Biology, Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China
Abstract: Precise modulation of histone gene transcription is critical for cell cycle progression. As a direct substrate of cyclin E/cyclin dependent kinase 2 (cyclin E/CDK2)， nuclear protein ataxia-telangiectasia (NPAT) is a crucial factor in regulating histone transcription and cell cycle progression. NPAT is localized in histone locus body (HLB) which is critical for regulating histone pre-mRNA process. Recent work revealed a series of NPAT-interacting proteins which played different roles in regulating the function and/or cellular localization of NPAT. This paper reviewed the recent work on the function of NPAT in regulating histone transcription and cell cycle and the underlying mechanisms.
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