Home > Browse Issues > Vol.39 No.6
Senescence of Hematopoietic Stem Cells and mTOR Signaling Pathway
Zeng Huihong1, Zhu Qingxian1, Kuang Bohai2, Fan Guangqin3, Shao Lijian3*
1Department of Histology and Embryology, Basic Medical College, Nanchang University, Nanchang 330006, China; 2Department of Medical Genetics and Cell Biology, Basic Medical College, Nanchang University, Nanchang 330006, China; 3School of Public Health, Nanchang University, Nanchang 330006, China
Abstract: Aging is a process in life but becomes a worldwide health issue with unresolved strategies to extend lifespan. Recent studies have shown that cellular senescence might play crucial roles in mammalian aging， specifically in adult stem cell senescence. We presently reviewed the evidence of hematopoietic stem cell senescence in physiological and pathological contexts. Understanding mechanisms of senescence have been made significant improvement including p53/p21 pathway， p16/Rb pathway， G-CSF/STAT3/BATF pathway and SASP. Depletion of senescent cells has become possible in vitro and in vivo. Activation of mTOR signaling pathway may be involved in the initiation and development of cellular senescence. These remarkable findings will provide us new opportunities for developing the mechanism-based strategies to prevent and/or deplete senescent cells in near future.
CN
EN