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The Underlying Mechanism of Calcium-Sensing Receptor in Alzheimer’s Disease
Feng Chenxi1, Wang Yuanyuan1, Bao Xiaoming2, Shen Suyan1, Wang Qinwen1, Xu Shujun1*
1School of Medicine, Ningbo University, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China; 2Ningbo No.2 Hospital, Ningbo 315010, China
Abstract: Alzheimer’s disease (AD) is a common neurodegenerative disease in the elderly. Nowadays the pathogenesis of AD is unclear. There is still lack of effective drugs for this disease. Calcium-sensing receptor (CaSR) has been found in different kinds of cells in the central nervous system. Soluble β-amyloid protein (Aβ) is one of the positive allosteric modulators of CaSR. CaSR is involved in cascade amplification of Aβ， inflammatory factors and vascular endothelial growth factor-A (VEGF-A) which is caused by Aβ. In this review， we summarized the roles and mechanisms of CaSR in the pathogenesis of AD. CaSR allosteric inhibitors are expected to be potential drugs for AD in the near future.
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