Heterogenesis in Cancer Metabolism

Abstract: The origination and malignant process of tumor is accompanied with metabolic disorder. The tumor is heterogeneous with multi-cellular interaction， which determines that the metabolic pattern of the tumor is highly heterogeneous and interacts with dynamic microenvironment rather than homogeneous and independent. Recent studies have shown that metabolic reprogramming of tumor cells or the cells located in the microenviroment creates favorable conditions for tumor growth and malignant progression. Multiple fuel choices of tumor guarantee tumor growth and metastasis without limitation of blood supply. Metabolic coupling within different components of tumor contributes to inflammation maintaining and anti-tumor immunity inhibition， therefore creates a favorable environment. This review will discuss how the flexible， heterogeneous and multi-interaction characters of tumor metabolism benefits the viability and influences clinical therapeutic effect.

CSTR: 32200.14.cjcb.2017.06.0014