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The Function of Polo-like Kinase 1 and Its Implication in Cancer Targeting Therapy
Li-Sha Ying, Hao-Xuan Tong1, Tian-Hua Zhou*
Department of Cell Biology, School of Medicine, Zhejiang University, Hangzhou 310058, China; 1College of Life Sciences, Zhejiang University, Hangzhou 310058, China
Abstract: Polo-like kinase 1 (PLK1)， a highly conserved serine/threonine kinase， plays pivotal roles in the regulation of cell cycle progression， including the activation of Cdc2/cyclin B， centrosome assembly and maturation， activation of the anaphase-promoting complex (APC) during the metaphase-anaphase transition， mitotic exit and cytokinesis. Recent studies show that PLK1 is generally overexpressed in various human tumors and possesses prognostic potential in cancer. Inhibition of PLK1 expression or activity induces the significant apoptosis of tumor cells， but not normal cells. Here we discuss the study on PLK1 and the application of PLK1 as a target for therapeutic intervention against cancer.
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