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Protection and Maintenance of Genomic Imprints in Mammal
Zhang Meiling, Zhu Yiran, Yang Shubao, Wang Chunfeng, Luan Weimin*, Ma Xin*
College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China
Abstract: Genomic imprinting is an epigenetic regulation phenomenon， which can restricts monoallelic expression to either the maternally or paternally inherited copy of the gene. Uniparental embryos leads to embryonic lethality indicates that protecting and maintaining of imprinting are critical in the process of genome reprogramming.Therefore， differential methylation status in imprinted loci which acquired during gametogenesis must be maintained and protected in the process of an active and passive demethylation after fertilization. To further study these molecules， especially the transcriptional co-repressor complex achieved via ZFP57/TRIM28 (zinc finger protein 57/tripartite motif-containing 28) interactions， which protect imprinted methylation sites during preimplantation embryonic development. In this review， the recent study progress of this complex and other related factor (eg.DPPA3， DNMT1) are summarized， and the epigenetic regulatory mechanism of these molecules are discussed
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