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The Regulation of Death Receptors in Tumor Cells
Hao Huahua, Kong Qinghong, Wang Guanlin*, Chang Kwenjen
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
Abstract: Tumor necrosis factor related apoptosis inducing ligand (TRAIL) can induce tumor apoptosis only after binding to its cognate death receptors (DRs) on the plasma membrane. The loss of DRs on the surface of cancer cells will result in tumor resistance to TRAIL-induced apoptosis and cell death. Recent studies have demonstrated that abnormal expression of death receptors may be the primary cause of the loss of cell surface death receptors. This review highlights the abnormal situation of death receptors in tumor cells， including the regulatory roles of transcription， post-translation modifications， trafficking and internalization， are possible mechanisms for the loss of death receptors in cell surface. This review provides a further reference theoretical basis for the development of multiple drugs combination therapy to overcome TRAIL resistance and to improve cancer therapy.
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