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Advance on the Anti-tumor Mechanism of Methylglyoxal
He Tiantian, Li Chunmei, Li Chenli, Chen Yuan, Meng Qinghe*, Lü Jianxin*
Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science,Wenzhou Medical University, Wenzhou 325035, China
Abstract: As a normal physiological metabolites， methylglyoxal (MG) is formed from various metabolic routes， among them glycolytic pathway provides the most important source. MG is mainly catalyzed by glyoxalasesystem， it converts to D-lactate finally. MG is highly reactive and it processes cell toxicity. MG is lower in many types of cancers. The anticancer effect of MG is due to its anti-proliferative properties， the abilities of inducing apoptosis and inhibiting tumor metastasis， it can also enhance immune system and increase sensitivity to antitumor agents. Further investigation of the mechanisms will provide evidences for next stage clinical research and make this compound to be a potential therapeutic agent， the aim of this review is to summarize the mechanisms of MG′s antitumor effect.
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