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Geminin and Eukaryotic DNA Replication Initiation
Dai Shangkun#, He Xiaoyan#, Liu Shuoshuo#, Deng Lei, Wang Biying, Fan Lifei*
School of Life Sciences, Inner Mongolia University, Hohhot 010021, China
Abstract: To ensure the initiation of DNA replication occurs only once per cell cycle， the initiation of DNA replication of eukaryotes is strictly regulated by multi-cooperative mechanisms. One mechanism is the Geminin mediated inhibition of DNA replication initiation， which is limited to higher eukaryotes and is vitally important for the faithful and stable transition of genetic material. Here， focusing on the relationship between Geminin and eukaryotic DNA replication initiation， we simply introduce the process of eukaryotic DNA replication initiation and the structure， spatio-temporal regulation of Geminin. Additionally， we detailedly discuss the way and mechanism of how Geminin regulates or inhibits eukaryotic DNA replication initiation. At last， we briefly summarize the opinions displayed and raise several questions about Geminin and eukaryotic DNA replication initiation， which require further researches and explorations.
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