Home > Browse Issues > Vol.37 No.12
Application and Progress of New Methods on Islet Transplantation
Sun Zhen1,2, Pan Qingjie3, Zhu Fenglong4, Wang Hongjun2*, Dong Xiao1*
1College of Life Science, Qingdao Agricultural University, Qingdao 266109, China; 2Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA; 3College of Animal Science, Qingdao Agricultural University, Qingdao 266109, China; 4Jimo Animal Husbandry and Veterinary Bureau, Qingdao 266109, China)
Abstract: Type 1 diabetes mellitus (T1D) is caused by the autoimmune destruction of pancreatic beta (β) cells， resulting in severe insulin deficiency. High blood glucose and Ketoacidosis symptoms are caused by insulin deficiency when beta cells are damaged. Islet cell transplantation is the most promising method for the T1D treatment. In this review， we summarized progresses and problems on islet isolation and transplantation in the T1D treatment. It also introduced the recent advance in current methods used to improve the efficacy of islet transplantation including using xenograft as islet donor， islet co-transplantation with mesenchymal stem cells， islet encapsulation with nanoparticles and induction of protective genes in islets.
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