Home > Browse Issues > Vol.37 No.12
Progress in Astrocytes Regulating GnRH Neurons
Li Liangjuan, Wu Xin, He Jieyu, Hu Yue, Wu Jianyun*
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Abstract: Astrocytes are specialized glial cells that outnumber neurons about 10 to 1. They are continuously distributed throughout the central nervous system and perform complex functions. In recent years， with the further research of astrocytes， new functions of astrocytes in animals were discovered and confirmed. It had been demonstrated that astrocytes participate in the regulation of animal reproduction by secreting PGE2， TGF-β1 or other glial factors to promote the activity and secretion of GnRH neurons. In this review， we mainly summarize the molecular mechanism of PGE2 and TGF-β1 so that can illuminate the roles of astrocytes in the regulation of animal reproduction.
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