Home > Browse Issues > Vol.37 No.11
Intestinal Stem Cell and Its Niche
Wen Min1,2, Jia Gang1*, Wang Kangning1, Zhao Hua1
1Animal Nutrition Institute, Sichuan Agricultural University, Yaan 625014, China;
2Tibet Vocational Technical College, Lasa 850000, China
2Tibet Vocational Technical College, Lasa 850000, China
Abstract: The epithelium of the intestine is one of the most rapidly self-renewing tissue in the body，the function of epithelium depends on the intestinal stem cells (ISCs) who reside at the base of the crypt. The cells surrounding the ISCs constitute a stem cell niche which prove a supporting microenvironment for the ISCs.With the identification of the ISC markers， the advancement of the lineage tracing and the organoid culture， our understanding of the origin and the mechanism regulating the prolifertion and differentiation of the ISCs has been improved. We briefly summarize the recent progresses about the ISCs and its niches in this paper.
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