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Progress in the Study of Sterol Regulatory Element Binding Protein-1 Signal Pathway
Qiao Hui, Liu Qingping*
Key Laboratory of Carbohydrate and Lipid Metabolism Research, College of Life Science and Technology, Dalian University, Dalian 116622, China
Abstract: Sterol regulatory element-binding protein-1 (SREBP-1) is one of the important nuclear transcription factors in lipid metabolism. SREBP-1 can regulate the biosynthesis of fatty acid， triglyceride and cholesterol. Abnormal expression of SREBP-1 and its target genes can cause a series of metabolic diseases such as insulin resistance， diabetes and fatty liver disease. Therefore， it is very important to know the role of various factors in SREBP-1 pathway. In this review， we summarize the feature of target genes regulated by SREBP-1， emphatically introduce the role of insulin and other upstream factors in regulating SREBP-1， which will contribute to a better idea for the guidance and treatment of various metabolism diseases.
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