Home > Browse Issues > Vol.37 No.6
Advances in Mesenchymal Stem Cell Therapy for Cutaneous Wounds
Zhu Ming, Xiao Nan, Huang Hong*, Xu Xiang*
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Abstract: Mesenchymal stem cells (MSCs)， also termed multipotent marrow stromal cells or mesenchymal stromal cells， are a heterogeneous population of plastic-adherent， fibroblast-like cells that can be easily obtained. MSC has low immunogenicity， high paracrine activity and multi-directional differentiation potential， showing great application potential in the field of tissue regeneration and wound healing. MSC-based therapy for cutaneous wounds have been proposed over ten years. Preliminary studies showed surprisingly good efficiency of MSC therapy both in animal models of skin injury and patients with skin damage. However， a lot of problems remain to be solved， and it is still a long way to apply this new therapy in clinical routine. This paper reviewed the role of MSC in cutaneous wound healing and current strategies to improve its efficacy， and proposed issues that should be addressed in future studies.
CN
EN