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The Diverse Roles of Small Rho GTPases in Cancer Cell Biology
Cao Xuemin1, Liu Yi2, Wunier1, Zhou Ling1, Fan Lifei1*
1School of Life Sciences, Inner Mongolia University, Hohhot 010021, China; 2No.4 Hospital of Baotou in the Inner Mongolia, Baotou 014030, China
Abstract: Primary tumors generally arose as a consequence of perturbing many of the characteristics of normal cell behavior. Such as， mutiple mutations and epigenetic changes affecting key genes that ultimately affected cell proliferation and survival， the acquisition of inappropriate characteristics in migration and invasion， and abnormal mitosis and cytokinesis that led to chromosomal instability. The small Rho GTPases contributed to multiple cellular processes that could affect cancer progression， including cell cycle progression， cell polarity， cell cytoskeletal rearrangement and cell-cell or cell-matrix contact regulated cell migration and invasion. Here， we summarized the recent research outcomes of the roles of small Rho GTPases in cancer cell progression， especially in cancer cell proliferation， survival， invasion， and migration; and in particular， we listed the potential possibilities of members in the Rho GTPases signaling pathway as new targets of cancer therapeutics.
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