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Cellular and Molecular Mechanisms in Amphibian Appendage Regeneration
Yang Li, Lin Gufa*
Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200120, China
Abstract: The ultimate goal of regenerative medicine is to stimulate the regeneration and functional reconstruction of damaged tissues and injured organs. While mammals， including humans， only have very limited regenerative ability， amphibians such as the Salamanders and the African clawed frog Xenopus can fully regenerate their lost tissues， such as appendages including the limb and the tail， in a particular period of life time. Here we review the cellular origins and molecular mechanisms in amphibian regeneration， where recent findings have provided new strategies for stimulating organ regeneration.
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