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The Role of Notch Signaling Pathway in Maintenance of Neural Stem Cells and Neurogenesis in Brain Germinal Zone
Shen Jianying1,2, Lin Ling2, Zheng Zhihong2*
1Research Base of TCM Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China; 2Research Center of Neurobiology, Fujian Medical University, Fuzhou 350122, China
Abstract: Adult neurogenesis is important for various cerebral injury and neurodegenerative disease. In the rodents and primates adult brain， it mainly occurs in the subventricular zone (SVZ) of the lateral ventricles (LV) and subgranular zone (SGZ) of the hippocampal dentate gyrus (DG). Coordinated proliferation and differentiation of adult neural stem cells (NSCs) is an important mechanism of adult neurogenesis. Adult neurogenesis process consists of a series of stages and each stage is discretely regulated by a variety of intrinsic and extrinsic factors. Notch signaling plays an important role in maintenance of the reservoir of adult NSCs. In this review， we will summarize the important role of Notch signaling for maintaining NSCs and neurogenesis in the adult SVZ and SGZ.
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