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Dmrt1 in Mammalian Germ Cell Development
Wei Yudong1,2, Shen Dan3, Cheng Huiling3, Li Na2, Hua Jinlian2*
1Innovation Experimental College of Northwest A&F University, Yangling 712100, China; 2College of Veterinary Medicine, Shaanxi Stem Cell Engineering and Technology Research Center, Northwest A&F University, Yangling 712100, China; 3College of Life Science, Northwest A&F University, Yangling 712100, China
Abstract: Dmrt1 is a member of the Dmrt (doublesex and mab-3 related transcription factor) family， which exists in mammals， birds， reptiles， nematodes， fruit flies and other species. It is known as the most conservative gene that participates in the gender differentiation. It is expressed in the male gonad during gender differentiation as well as in the adult testis specifically， with a significant effect on the formation and function of male gonads. This review mainly focuses on the research and problems which exist in mammalian germ cell development and differentiation regulation by Dmrt1.
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