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Research Progress of the Molecular Mechanism of Autophagy Regulation
Li Lexing, Dai Hanchuan*
Animal Biochemistry Teaching and Research Office of Basic Veterinary Department, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
Abstract: Autophagy， as an evolutionarily conserved catabolic process， involves in intracellular long-lived protein and damaged organelles catabolism. Autophagy plays an important role in a variety of life processes， such as the cell homeostasis， tumor， heart failure， aging-related diseases， neurodegenerative disease and infectious diseases. Ubiquitin protein system， mTOR signaling pathway， microRNA and caspase mediate autophagy regulation. Therefore， we summarized the research progress of the autophagy process， function and molecular mechanism in the article to help research autophagy mechanism and provide theoretical basis for treating certain diseases.
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