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Lats1 is the Key Component of Hippo Signaling Pathway: A New Tumor Molecular Biomarker and A Potential Therapeutic Target
Chen Kehong1, Wang Delin2*
1Department of Urology, Chongqing Red Cross Hospital, People’s Hospital of Jiangbei District, Chongqing 400020, China;2Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Abstract: lats1 is one of the key components in hippo signaling pathway and suppresses occurrence and development of tumors by down-regulating the target gene yap. Decrease or loss of the expression of lats1 is found in a wide variety of tumor tissues， and it is regarded as a tumor suppressor gene. Therefore， lats1 might be a new malignant tumor molecular biomarker and a potential therapeutic target. In this paper， we reviewed the research advances of lats1 in this filed.
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