Home > Browse Issues > Vol.37 No.2
Protein Quality Control
Shi Hao, Sun Dayan, Li Bin, Fang Hezhi*, Lü Jianxin*
School of Laboratory Medicine and Life Sciences, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical University, Wenzhou 325035, China
Abstract: Protein quality control (PQC) is a surveillance system ensuring the proper folding of newly synthesized protein and degradation of damaged or misfoldered protein. Dysregulation of PQC system has been implicated in cancer， aging and other degenerative diseases. To provide a comprehensive understanding of PQC in human diseases， the role of PQC in cytosol， endoplasmic reticulum and mitochondria are discussed in this review.
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