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Molecular Mechanisms of Sensing and Responding to Cytosolic Microbial DNAs
Cui Ye, Li Senlin, Wang Qiang, Wang Chen*
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Innate immunity is the first line of host defenses against pathogens. The microbe-specific pathogen associated molecular patterns (PAMPs)， including the microbial nucleic acids， are detected by germ-line encoded pathogen recognition receptors (PRRs)， and trigger immune responses. PRRs also sense the aberrant DNAs or RNAs released by host cells， inducing autoimmune diseases. Stimulator of interferon genes (STING) has recently been uncovered as a hub signaling protein on ER， mediating the cytosolic sensing of DNAs and CDNs in innate immunity. Here， we summarize the recent advances of the STING signaling， and highlight the important issues for future investigations.
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