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Recent Progress of microRNA in the Pathogenesis of Human Uterine Leiomyomas
Liu Qin1,2, Xu Mingjuan1*
1Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2Shanghai 7th People’s Hospital, Shanghai 200011, China
Abstract: MicroRNA (miRNA) is a small non-coding single strand RNA molecule. The functions of miRNA are broadly involved in cell proliferation， differentiation， apoptosis and migration. Recent findings indicated that miRNA also played an important role in the pathogenesis of human uterine leiomyomas， which includes cell transformation， tissue resembling， angiogenesis and inflammation. It may be applied as not only a new way to explore the pathogenesis of human uterine leiomyomas， but also a new target for disease diagnosis， therapy and prognosis. In this review， the most newly progress of miRNA in the pathogenesis of human uterine leiomyomas will be summarized.
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