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Effects of Chemokines on Cancer


Jie Zheng*
Department of Pathology and Pathophysiology, Institute of Molecular Pathology, School of Basic Medical Science, Southeast University, Nanjing 210009, China
Abstract: Although chemokines have been thought of primarily as controlling leukocyte trafficking in inflammation and hematopoiesis, there is now accumulating evidence indicates that they are also involved in a number of tumor-related processes, such as the leukocyte infiltrate, angiogenesis, tumor cell growth, survival, invasion, and metastasis. Manipulation of the tumor chemokine network could have therapeutic potential in cancers.


CSTR: 32200.14.cjcb.2007.03.0001