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Advances of Non-coding RNAs Regulation in Epithelial-mesenchymal Transition and Cancer Stem Cells
Yang Qiong1,2, Li Yongjun1, Fang Xiangdong1*
1Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics,Chinese Academy of Sciences, Beijing 100101, China; 2University of Chinese Academy of Sciences, Beijing 100049, China
Abstract: Cancer stem cells (CSCs)， possessing self-renewal properties and the capacity to differentiate into the heterogeneous cancer populations， play an important role in tumor metastasis and relapse. It is reported that cancer stem cells can be generated when cancer cells go through epithelial-mesenchymal transition (EMT). Noncoding RNAs (ncRNAs)， as key regulators of gene expression， could contribute to the acquisition of stem cell trait by regulating EMT process. This review focused on current understanding of the regulation mechanisms of EMT in CSCs formation and the role of ncRNAs in EMT control.
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