Home > Browse Issues > Vol.36 No.11
Carbonic Anhydrase IV and Human Diseases
Wan Xiangxiang1, Song Haojun2, Chen Shengcan1, Li Peifei1, Fang Ying1, Ding Xiaoyun2*, Guo Junming1*
1Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, China; 2Department of Gastroenterology, Ningbo First Hospital, Ningbo 315010, China
Abstract: Carbonic anhydrase 4 (CAIV) is one of the 12 kinds of human-related carbonic anhydrases. It anchored in the cytoplasmic membranein mainly by glycosylphosphatidylinositol. The expression of CAIV has been identified in multiple organs of mammals. CAIV efficiently catalyzes the reaction of CO2 hydration and HCO3 – dehydration， and plays an important role in many physiological response， such as acidification of urine， alveolar ventilation， etc. CAIV gene expression changes， structural instability and activity loses are closely related to the development of many human diseases. CAIV can also be applied as a drug target for treatment of diseases. To this end， this paper draws a summary for the association between CAIV and the pathophysiology of human diseases.
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