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The Specificity and Turnover of PIP2 Signal
Xu Jiaxi1, Yan Xiangdong2, Si Man1, Ding Jie1, Du Yuwei1, Zhang Hailin1*
1Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China;
2Hebei Traditional Chinese Medicine Research Institution, Shijiazhuang 050031, China
Abstract: Phosphatidylinositol-4，5-bisphosphate (PIP2) is a type of phosphoinositide enriched in the inner leaflet of the plasma membrane. Though PIP2 only comprises about 1% of plasma membrane phospholipids， it serves as a precursor of the second messengers， and stabilizes or activates many important membrane proteins. Cellular PIP2 levels are dynamically regulated. When the metabolic regulation of PIP2 is changed， the resulted changes in the local concentration of PIP2 will alter the function of a specific protein. This paper reviewed the researches on some aspects of PIP2 signal and its metabolic characteristics in the last two decades.
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