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Mitochondrial Adenine Nucleotide Translocator
Yan-Ping Wang, Jing Gao*
School of Life Sciences, School of Medicine, Nanjing University, Nanjing 210093, China
Abstract: Adenine nucleotide translocator (ANT)， a 32 kDa protein located in the mitochondrial inner membrane， appears to act as a bi-functional protein. On the one hand， ANT is a vital， specific antiporter which contributes to the exchange of cytosolic ADP and mitochondrial ATP. On the other hand， ANT can participate in the formation of the mitochondrial permeability transition pore (PTP)， a nonspecific pore that is an important mediator of apoptosis. This paper summarizes some of the recent advances in the research on the structure， characterization， function of ANT and also the activity of ANT which is related to apoptosis.
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