Wnt Signaling Pathway in Self-renewal and Expansion of Hematopoietic Stem Cell

Abstract: Wnt signaling molecules are highly conserved stimulating factors in evolution， which are widely expressed in various tissues of invertebrate and vertebrate. They are highly valued for their important biological functions in a variety of biological processes including growth， development， metabolism and regulation of stem cells. Based on the activation pathways， Wnt molecules can be divided into canonical and non-canonical types， acting on Wnt/β-catenin signal pathway， Wnt/JNK signaling pathway and Wnt/Ca2+ signaling pathway， respectively. Recent studies have shown that the Wnt signaling pathways play important roles in self-renewal of hematopoietic stem cell. This article mainly discussed the molecular mechanisms of canonical and non-canonical Wnt signaling pathways， the research progress of Wnt signaling pathway in self-renewal of hematopoietic stem cell in recent years and the interaction between Wnt and other signaling pathways in hematopoiesis， hematopoietic maintenance and reconstitution.

CSTR: 32200.14.cjcb.2014.11.0012