Phosphatidylinositol/Phosphatidylcholine Transfer Proteins

Abstract: Phosphatidylinositide/phosphatidylcholine transfer proteins (PITP) are ubiquitous proteins in all eukaryotic cells， such as metazoans， fungi and higher plants. PITP binds and exchanges one molecule of either phosphatidylinositide or phosphatidylcholine and facilitates the transfer of these lipids between different membrane compartments in vitro. PITP regulate secretory vesicles formation， trafficking， cell budding and PLC-mediated signaling and neurological degradation in metazoans; lipid metabolism and membrane trafficking in yeast; signaling in plant development. Herein， we review recent advances in PITP in biological and cellular levels and the intriguing mechanisms by which PITP execute their functions are still unknown.
    

CSTR: 32200.14.cjcb.2007.02.0009