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Mechanism of Tumorigenesis Regulated by Axin
Li-Hua Jin*, Qin-Xi Li1, Zhi-Yun Ye1
Research Center of Biomedical Engineering, School of Medicine, Xiamen University, Xiamen 361005, China; 1Department of Biomedical Sciences, School of Life Sciences, Xiamen University, Xiamen 361005, China
Abstract: Cell signaling pathways involved in tumorigenesis are the focus of biomedical research nowadays. Axin， a tumor suppressor， is an essential scaffold protein participating in a network of separate but interacting signaling transduction pathways. Emerging evidence indicates its diverse roles in Wnt， JNK， p53， TGF and G-protein signaling pathways to regulate cellular fate determination， growth and proliferation. In this light， there has been intense investigation into the pivotal nature of Axin in assuring appropriate cell cycle progression and the detrimental effect of AXIN1 mutation that leads to human cancer. This review starts from the original identification of Axin and introduces the tumor suppressor roles of Axin in multiple signaling pathways with the emphasis on reported mutational study of AXIN1 gene in human tumorigenesis.
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