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Function of c-Myc and Its Target
Yang Bai1,2, Jian Ye1,2, Jing-Ze Wang1*
1State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, the Chinese Academy of Science, Beijing 100080, China; 2Graduate University of the Chinese Academy of Sciences, Beijing 100049, China
Abstract: c-Myc is an evolutionarily conserved transcriptional regulator which has structure of basic region/helix-loop-helix/leucine zipper (b/HLH/LZ). c-Myc can heterodimerze with Max to transactivate its target genes through binding the consensus sequence E box within the promoter region， it can also positively or negatively regulate other target genes. c-Myc participates the regulation of cell proliferation， differentiation， growth， apoptosis， cell cycle progression， cellular immortalization and oncogenic transformation. For hunting c-Myc targets， some new high-throughput technologies including oligonucleotide microarrays， bioinformatics， chromatin immunopriciptation assay， serial analysis of gene expression， et al.. This will be important to elucidate the relationship between c-Myc structure and its function.
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