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Cell Counting Factor and Its Regulation on the Size of Multicell in Dictyostelium discoideum
Chun-Xia Yang, Li Li, Shuo Yang, Da-Lei Wang, Lian-Sheng Hou*
School of Life Sciences, East China Normal University, Shanghai 200062, China
Abstract: During the development of Dictyostelium discoideum， the size of multicell is regulated by counting mechanism. The cell number counting factor (CF) is a bioactive molecule composed of countin， CF50， CF45-1 and other subunits， and have important effects on the regulation of cells body size. This article review these subunits and their functions， and the mechanism of cAMP pulse， glycometabolic pathway， AKt/PKB pathway involved in regulation of CF.
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